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screening in cultured myotubes and mouse skeletal muscle mass, elucidated tomatidine as a little molecule inhibitor of skeletal muscle atrophy.The latter effect is mediated through the hitherto unfamiliar skill of DYRK1B to activate the PI3K/mTOR/AKT pathway, which is understood to stabilize GLI proteins [7, 26]. The PI3K/mTOR/AKT pathway is Among